Release form, packaging, and composition of the drug Cymeven®
Lyophilisate for solution for infusion in the form of a porous mass compacted into a tablet, sometimes in the form of separate parts of the tablet, white or almost white; The reconstituted solution is a clear or slightly opalescent, colorless, or slightly yellowish liquid.
Clinico-pharmacological group: Antiviral drug
Pharmaco-therapeutic group: Antiviral agent
Pharmacokinetics
Suction
After infusion of ganciclovir at a dose of 5 mg/kg for 1 hour to HIV- and CMV-infected patients or adult patients with AIDS, the total area under the concentration-time curve (AUC0-24) ranges from 21.4 ± 3.1 to 26.0 ± 6.06 μg x hour /ml The maximum concentration of the drug in plasma (Cmax) ranged from 7.59±3.21 and 8.27±1.02 to 9.03±1.42 µg/ml.
Distribution
The volume of distribution of ganciclovir after intravenous administration correlates with body weight and, upon reaching an equilibrium concentration, is 0.5-0.8 l / kg. The concentration of the drug in the cerebrospinal fluid is 0.25-5.67 hours after intravenous administration of ganciclovir at a dose of 2.5 mg/kg every 8 or 12 hours is 24-67% of plasma concentrations and is equal to 0.50-0.68 mcg/ml. Communication with plasma proteins – 1-2%.
Metabolism and excretion
After intravenous administration at doses of 1.6 to 5.0 mg/kg, the kinetics of ganciclovir is linear. The main route of elimination is renal excretion of unchanged drugs by glomerular filtration and tubular secretion. In patients with normal renal function, 89.6 ± 5.0% of the intravenously administered dose of ganciclovir is found in the urine unchanged. In individuals with normal renal function, systemic clearance ranges from 2.64±0.38 to 4.52±2.79 ml/min/kg, and renal clearance ranges from 2.57±0.69 to 3.48±0.68 ml/min/kg, which corresponds to 90-101% of the administered ganciclovir. The elimination half-life in persons without renal insufficiency ranges from 2.73 ± 1.29 to 3.98 ± 1.78 hours.
Pharmacokinetics in special groups of patients
kidney disease
Hemodialysis reduces plasma concentrations of ganciclovir after intravenous and oral administration at doses of 1.25-5.0 mg/kg by approximately 50%.
When using an intermittent hemodialysis regimen, the clearance rates of ganciclovir range from 42 to 92 ml/min, and the half-life of the drug during dialysis is 3.3-4.5 hours. With continuous dialysis, the clearance of ganciclovir was lower (4.0-29.6 ml/min), but in the period until the next dose of the drug, a larger percentage of the dose was removed from the body. With intermittent hemodialysis, the fraction of ganciclovir removed in one session of hemodialysis ranges from 50% to 63%.
Elderly patients
Studies have not been conducted on persons over 65 years of age.
Indications for Cymeven®
- treatment of life-threatening or vision-threatening overt CMV infection in people with immunodeficiencies, including AIDS;
- prevention of overt CMV infection in patients after organ transplantation.
Dosing regimen
Adults and children over 12 years old
The standard dosage for the treatment of CMV retinitis
Initial therapy: IV infusion at a dose of 5 mg/kg of body weight for 1 hour, every 12 hours (10 mg/kg/day) for 14-21 days (for patients with normal renal function).
Maintenance therapy: 5 mg/kg by intravenous infusion over 1 hour, daily for 7 days a week or 6 mg/kg daily for 5 days a week.
Contraindications for use
the absolute number of neutrophils is less than 500 cells in 1 μl or the number of platelets is less than 25,000 cells in 1 μl or the hemoglobin level is less than 8 g / dl;
children’s age up to 12 years;
hypersensitivity to ganciclovir, valganciclovir, or any other component of the drug.
due to the similarity in the chemical structure of ganciclovir, aciclovir, and valaciclovir, cross-hypersensitivity reactions between these drugs are possible.
With caution, renal failure.
Use during pregnancy and lactation
Category C drug (according to the FDA classification – U.S. Food and Drug Administration).
During treatment with ganciclovir, women of childbearing age should be advised to use reliable methods of contraception. Men are advised to use a barrier method of contraception during treatment and for at least 90 days after treatment.
In animal studies, the drug has been shown to be teratogenic. The safety of ganciclovir in human pregnancy has not been established. Prescribing the drug to pregnant women should be avoided unless the potential benefit to the mother outweighs the possible risk to the fetus.
Peri- and postnatal development after exposure to ganciclovir have not been studied, but it cannot be ruled out that ganciclovir may be excreted in milk and cause serious adverse reactions in the nursing infant. Nursing mothers should be instructed to stop breastfeeding while taking Cymeven.
Application for violations of kidney function
Use caution in renal failure. Doses should be adjusted according to QC.
Use in children
Contraindication: children under 12 years of age.
The efficacy and safety of ganciclovir in children, including those with congenital and neonatal CMV infection, have not been established. Because of the potential for late carcinogenicity and reproductive toxicity, extreme caution should be exercised. The benefits of treatment must outweigh the potential risks.
Use in elderly patients
Studies have not been conducted in persons over 65 years of age. Since the renal function is often reduced in the elderly, ganciclovir should be prescribed strictly taking into account renal function.
Payment and delivery:
https://pahrmacydiscount.com/delivery
Delivery CYMEVEN from Europe
Delivery CYMEVEN from the Czech Republic
Delivery CYMEVEN from Germany
Delivery CYMEVEN from Russia
Delivery CYMEVEN from France
Delivery CYMEVEN from Italy
Buy CYMEVEN in Europe
Buy CYMEVEN in the Czech Republic
Buy CYMEVEN in Germany
Buy CYMEVEN in Russia
Buy CYMEVEN in France
Buy CYMEVEN in Italy
Delivery of CYMEVEN in Moscow
Delivery of CYMEVEN in Kiev
Delivery of CYMEVEN in Minsk
Delivery of CYMEVEN in London
Delivery of CYMEVEN in St. Petersburg
Delivery of CYMEVEN in Kharkov
Delivery of CYMEVEN in Paris
Delivery of CYMEVEN in Madrid
Delivery of CYMEVEN in Munich
Delivery of CYMEVEN in Brussels
Delivery of CYMEVEN in Amsterdam
Delivery of CYMEVEN in Copenhagen
Order Form:
- The name of the medicine
- Dosage
- Brand
- Quantity
Send to e-mail doradorapharm@gmail.com
In search engines are looking for
Купить ЦИМЕВЕН 500 МГ, Цена ЦИМЕВЕН 500 МГ
Купити ЦИМЕВЕН 500 МГ, Ціна ЦИМЕВЕН 500 МГ
Kupit ЦИМЕВЕН 500 МГ, Ceni ЦИМЕВЕН 500 МГ
Buy CYMEVEN 500 MG, Price CYMEVEN 500 MG
Acheter CYMEVEN 500 MG, Prix CYMEVEN 500 MG
Para comprar CYMEVEN 500 MG, Precio CYMEVEN 500 MG
Zu kaufen CYMEVEN 500 MG, Preis CYMEVEN 500 MG
Kupić CYMEVEN 500 MG, Cena CYMEVEN 500 MG
Koupit CYMEVEN 500 MG, Cena CYMEVEN 500 MG
للشراء CYMEVEN 500 MG, السعر CYMEVEN 500 MG
Satın almak CYMEVEN 500 MG, fiyat CYMEVEN 500 MG
Comprare CYMEVEN 500 MG, prezzo CYMEVEN 500 MG
Sotib olish uchun CYMEVEN 500 MG, Narxlari CYMEVEN 500 MG
Για να αγοράσετε CYMEVEN 500 MG, Τιμή CYMEVEN 500 MG
შეძენა CYMEVEN 500 MG, ფასი CYMEVEN 500 MG
Satın almaq üçün CYMEVEN 500 MG, Qiymət CYMEVEN 500 MG
Para comprar CYMEVEN 500 MG, Precio CYMEVEN 500 MG
Comprar CYMEVEN 500 MG, Preço CYMEVEN 500 MG
Popular medicine from Czech Republic, to buy medicine from France, delivery of medicine from Germany, how to buy medicine from Czech Republic to America, how to buy medicine from France to England, Online Pharmacy from Germany, Internet Pharmacy from Czech Republic, International Pharmacy in Europe, Pharmacy from Europe, Medical cosmetics from France, Natural cosmetics from Europe or Canada, Vitamins from Europe or America, Nutritional supplements from Europe and Poland, Products from Czech Republic, to order medicine from Germany
Popular prescription drugs from the Czech Republic, to buy prescription drugs from France, delivery of prescription drugs from Germany, how to buy prescription drugs from the Czech Republic to America, how to buy prescription drugs from France to England, how to order prescription drugs from Europe, delivery of prescription drugs from Europe and across Euro