Pharmacological action – hematopoietic.
Pharmacodynamics
Hematopoietic growth factor.
Pegfilgrastim is a covalent conjugate of filgrastim, a recombinant human granulocyte colony stimulating factor (G-CSF), with one molecule of 20 kDa polyethylene glycol (PEG), with a prolonged action as a result of a decrease in renal clearance. Similar to filgrastim, pegfilgrastim regulates the formation and release of neutrophils from the bone marrow, markedly increases the number of neutrophils with normal or increased functional activity (chemotaxis and phagocytosis) in the peripheral blood within 24 hours and causes a slight increase in the number of monocytes and / or lymphocytes.
Like other hematopoietic growth factors, G-CSF can stimulate endothelial cells in vitro.
A transient increase in white blood cells (leukocytosis) is an expected consequence of pegfilgrastim therapy. corresponds to its pharmacodynamic effects. No side effects directly related to such leukocytosis have been described.
Single administration of pegfilgrastim after each cycle of myelosuppressive cytostatic therapy reduces the duration of neutropenia and the incidence of febrile neutropenia similarly to daily administration of filgrastim.
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